CARDIOVASCULAR

Cardiovascular disease is one of the leading causes of death for women and men in the world.

Hereditary cardiovascular disorders can be either symptomatic or asymptomatic until a person experiences a major and dangerous for life, health event. People may want to know their genetic makeup, in order to prevent or manage their or their family’s state of health.

Cardiovascular disease can be caused by hereditary disorders that increase the risk of serious events such as cardiac arrest, heart failure, sudden cardiac death and stroke.

Some of the typical hereditary cardiovascular diseases are arrythmias, hypertension, hypercholesterolemia, hyperlipoproteinemia, aortic disorders, cardiomyopathy, congenital heart disorders.

In DNAMyself, using whole exome sequencing we test for likely pathogenic/pathogenic and variants of unknown significance (VUS) yet in 361 genes associated with hereditary cardiovascular disorders which can be managed, prevented or treated. By sequencing all your functional genome we aim on getting the most information possible in applied genetics customised for you only.

The test can detect single nucleotide variants (SNVs), small insertions and deletions (indels).

SHOC2, NR2F2, FBXO32, GLB1, ATP7A, MAP2K1, DNAAF5, TGFBR1, KCNE2, RRAS, RYR2, DNAI1, IL1B, LMNA, COL3A1, TGFB2, PKD1L1, SCNN1G, DTNA, DSE, ACVR2B, CRYAB, VCL, TTR, ABL1, SOS2, SGCA, LEFTY2, JAG1, GATA4, BGN, SLC39A13, SGCD, FLNA, RIT1, COL2A1, MED12, APOC2, CHST14, ALMS1, MTO1, PCCB, MAT2A, ACTB, CALM1, GFM1, ACTA2, SCN2B, SMAD3, CBL, NOTCH1, ADAMTSL4, ACAD9, NAA15, TGDS, SMAD6, BCOR, SOS1, VCP, PPA2, FOXH1, CRELD1, NF1, PPP1CB, BAG3, MMP21, DNAAF1, NRAS, TLL1, KCNJ2, PTPN11, KIF6, SCN10A, MYH6, TTN, SDHA, SGCB, COL5A1, MLYCD, NOS1AP, FKTN, CCDC40, ACTG1, AGK, ACADVL, GJA1, GDF1, TRDN, FXN, RASA1, KCNJ8, KCNJ5, DNAH11, DNAI2, MYPN, TNNC1, NKX2-6, TRPM4, GJA5, UPF3B, VCAN, APOC3, ZIC3, KCNE5, NSUN2, MAP2K2, CALM3, CAPN3, CAV3, GATA5, MYL4, CAV1, KCND2, TOR1AIP1, FBN1, MEIS2, GMPPB, TGFBR2, PLN, TGFB3, APOA5, HRAS, ABCG8, EEF1A2, CALR3, ACVR1, SCO2, ACVRL1, MYBPHL, SKI, CHD4, CREB3L3, ACTN2, RBCK1, BMPR2, APOB, DSP, HAND1, SLC22A5, FBLN5, FOXRED1, MYCN, GPC3, MYOT, CACNA1C, ACTC1, GBE1, SGCG, FHL1, ELN, ETFB, RASA2, TCAP, LDLR, SPRED1, FKRP, DSG2, DES, DNAAF2, MYH7, SLC2A10, ZNF469, INVS, FLNC, HADHA, RBM10, DHCR7, TBX20, ABCG5, POMT1, KCNA5, PLEKHM2, LZTR1, ACTA1, TNNT2, SPAG1, APOA1, TBX4, MYBPC3, DMD, SALL4, GPD1L, PLEC, CASQ2, DNAJC19, LIPA, DNAH5, GAA, KRAS, TNNI3K, COL1A2, SLC25A20, CDK13, LMF1, PNPLA2, CTNNA3, SCN1B, TFAP2B, CCDC103, LDB3, FKBP14, SMAD4, B3GAT3, LAMP2, DNAL1, TMEM70, GUSB, CACNB2, CDH2, DNAAF3, ANKS6, ZFPM2, FGF12, PYCR1, KCNK3, RAF1, PRKAG2, FOXF1, HCN4, CCDC39, NUP155, TECRL, EIF2AK4, BRAF, COL5A2, NSD1, NDUFAF2, ZMYND10, COL1A1, KCNE3, DBH, PCSK9, RBM20, APOE, EPG5, TNNI3, SCN5A, TMEM43, ADAMTS17, ATP6V0A2, ALPK3, GPIHBP1, EFEMP2, PKP2, HOXA1, FBN2, ELAC2, NOTCH2, ETFA, TBX1, PCCA, CBS, LDLRAP1, AGL, PLOD1, SCN3B, SELENON, MFAP5, ETFDH, LRRC10, SCNN1B, CALM2, ABCC9, DSC2, B4GALT7, AKAP9, NKX2-5, ENPP1, TAB2, LPL, CHD7, PITX2, NEXN, MYL2, TSFM, GLA, KCND3, CPT2, ABCA1, COL11A1, KCNE1, EFTUD2, MYL3, TBX5, HFE, DYSF, ADAMTS2, RANGRF, COX15, ABCC6, ANK2, GTPBP3, JPH2, RMND1, KCNQ1, SMCHD1, SLC25A4, XK, ADAMTS10, SEMA3A, COL11A2, CTC1, PRDM16, ENG, IL1A, SPEG, JUP, DOLK, ALDH18A1, CSRP3, KCNH2, NFU1, GATA6, TPM1, NODAL, EMD, MYH11, PRKD1, GATAD1, CACNA2D1, VPS13A, SMAD2, ANO5, ATP6VIA, COL4A, C1S, LOX, PRDM5, ATP6V1E1, B3GALT6, SKI, ACVR1, FOXE3, MYLK, CIR, GORAB, CJA5, GNAI2, KCNAB2, NPPA, SCN4B, SNTA1, AARS2, COA5, COA6, ILK, TAZ, TK2, ANKKRD1, FLNC, HADHB, KARS, LAMA4, MRPL3, MRPL44, MYOZ2, NDUFB11, NEBL, PDLIM3, TTR, SMAD9, AFF4, CCDC11, EVC, EVC2, FLNA, CREBBP, PLD1, ZEB2, COLGALT1

 

NUTRIGENETICS

Nutrition is crucial for our health. However different people react differently to different types of food and this can happen due to every person’s genes. The more knowledge we have on genes, the most actual and complete information we get! This is the reason why despite the fact that most companies use genotyping tests that share limited data on genes, we test your whole functional genome.

The DNAMyself tells you how specific genetic variants in your DNA can affect the way you respond to nutrients in order to customize and thus optimize your diet.

The small differences in DNA observed among different people, can influence how a gene provides the instructions to make proteins and enzymes. By customizing your diet based on our DNAMyself report, you can positively change your risk of developing certain health conditions, optimise your energy levels and maintain a healthy weight.

Some of the conditions and areas covered by the test are: obesity, metabolic syndrome, fat metabolism (regulation and sensitivity), carbohydrate metabolism (regulation and sensitivity), omega 3/omega 6 ratio, circadian rhythm and appetite, melatonin and insulin secretion, energy production and regulation, diabetes type II, homocysteine levels, methylation, levels of methionine, levels of cysteine, levels of choline, inflammation, estrogen and xenobiotics metabolism, oxidative stress, risk of low vitamin levels such as vitamin A, B12, C and D, risk of low iron levels, intolerances in caffeine, alcohol, salt, gluten, histamine and lactose. 

The test can detect single nucleotide variants (SNVs), small insertions and deletions (indels) in 50 genes and you get a fully customized report of 60 pages which includes your genetic results, customized needs in different vitamins etc plus food tables.

ADD1, ADIPOQ, ADORA2A, AGER, AGT, ALDH2, APOA5, ARDB2, BCO1, CAT, CBS, CLOCK, COMT, CYP1A1, CYP1A2, CYP1B1, CYP2R1, FABP2, FADS1, FADS2, FTO, FUT2, G6PC2, GHRL, GPX1, HNMT, IL-1 alpha, IL-1 beta, IL-6, MC4R, MCM6, MnSOD, MTHFD1, MTHFR, MTNR1B, MTR, MTRR, NQ01, PLIN, PPARG, SLC23A1, SLC2A2, TCF7L2, TMPRSS6, TNF-alpha, UCP1, VDBP, VDR

DERMATOLOGY (SKINCARE)

It is well established, that genetics play a major role in skin appearance and skin health at all ages.

The DNAMyself test offers information for you on your skin issues and its needs. That way it helps you to customize your everyday routine and at the same time make plans on how you can help your skin health and protection.

By applying all the information you can get from your genes you can point towards success when it comes to the science of dermatology.

Some of the areas covered in this test are, if someone is prone to psoriasis, to atopic dermatitis (eczema) or varicose veins, your skin hydration needs, skin glycation, vitamin A needs, skin oxidation, vitiligo, skin ageing, skin tanning, pigmented spots, skin photosensitivity and melanoma.

In all these areas you receive a customized report with instructions on how you can act regarding your results.
The test can detect single nucleotide variants (SNVs), small insertions and deletions (indels) in 27 genes.

AGER, AQP3, BAP1, BCO1, BNC2, CAT, COL6A5, CDK4, CDK10, CDKN2A, CYP2R1, DDR1, EPHX1, EXOC2, FLG, GC, GPX1, GSTP1, IL12B, IL13, IL23R, IRF4, KIF3A, MC1R, MITF, MTHFR, SLC23A1, SOD2, TNIP1, TYR, VDR

DIABETES

Diabetes is a disease that occurs when the blood glucose level is higher than it should (hyperglycemia).
Normally, insulin, a hormone produced by the pancreas, helps glucose from food to enter the cells in order to be used downstream for energy. Sometimes, however, glucose remains in the blood and does not reach the cells due to the fact that the body doesn't make enough or any insulin (type 1 diabetes), or doesn't use insulin well (type 2 diabetes).

The DNAMyself diabetes panel is used to identify genetic variants associated with type 1 and type 2 diabetes since diabetes can cause health problems, such as cardiovascular disease, kidney disease and nerve damage.
Using Whole Exome Sequencing (WES) technology, we can identify genetic variants in 63 genes that affect insulin production, cellular signalling and metabolism. Through testing you can gain information on your risk, management and lifestyle changes.

The test can detect single nucleotide variants (SNVs), small insertions and deletions (Indels) in 63 genes.

ABCC8, BBS7, IL6, AVP, AVPR2, SIM1, CCR5, CTLA4, INS, LEP, BBS12, NEUROG3, PCSK1,
NEUROD1, EIF2AK3, SDCCAG8, GLIS3, MKS1, BBS4, BBS5, GCK, HLA-DRB1, WFS1, PTF1A, HNF1B, CEL, AQP2, KCNJ11, HNF4A, BDNF, PDX1, ITPR3, FOXP3, POMC, WDPCP, GNAS, RFX6, MAGEL2, NTRK2, ALMS1, BBS1, BBS10, IL2RA, BBS9, MC4R, LEPR, OAS1, PTPN22, BBS2, HNF1A, ARL6, CEP290, MKKS, TTC8,APPL1, BLK, INSR, KLF11, PAX4, PPARG, UCP2, ZFP57, GLUD1, HADH

 

ALZHEIMER’S / DEMENTIA

Alzheimer's disease and dementia are neurodegenerative disorders.
An individual with a family history of Alzheimer's disease, or dementia or individuals with symptoms of these conditions, such as tremors, memory loss, and cognitive impairment may be interested on this genetic panel.

The DNAMyself test via Whole Exome Sequencing, can provide further information for each interested individual, through the analysis of 42 genes related to these two conditions.

Both diseases can result as a consequence between genetics and each one’s lifestyle and as it is known until now the early form of Alzheimer’s disease (before 65 years old) has a strong genetic backgound.

The test can detect single nucleotide variants (SNVs), small insertions and deletions (indels) in 42 genes.

ABCA7, CHMP2B, FUS, SNCA, DCTN1, FBXO7, PRNP, LRRK2, GBA, TYROBP, PRKRA, PINK1, PSEN2, APOE, MPO, GRN, TAF1, PRKN, APP, SNCB, A2M, GCH1, PLA2G6, POLG, VPS35, EIF4G1, HTRA2, PSEN1, CSF1R, AAAS, ATP13A2, HFE, DNMT1, SNCA, ATP1A3, TREM2, UCHL1, TH, SLC6A3, MAPT, PARK7, ACE

OBESITY

Obesity results from the chronic imbalance between the energy someone consumes and the one that is used up from the body. It increases the risk of health problems, such as heart disease, diabetes, high blood pressure and cancer. In some cases, obesity, seems to run in families and have a strong genetic component. The related genes affect appetite regulation, energy expenditure and lipid metabolism.

The DNAMyself test can help in risk acknowledgment, management and to provide motivation for behavioural change in each individual.

Via Whole Exome Sequencing (WES), the test can detect single nucleotide variants (SNVs), small insertions and deletions (indels) in 51 genes.

PRMT7, ADRB3, SIM1, LEP, UCP3, CARTPT, GRIA4, MT-CYB, DDHD2, SMARCA4, BBIP1, SDC3, GLDC, ZNF778, KIDINS220, SCN1A, DIP2C, TRAPPC9, DNM1L, DEAF1, AQP7, POMC, SYNE2, ENPP1, GNAS, POLG, EMC1, DIXDC1, RYR1, FAM177A1, NTRK2, ARL14EP, AHDC1, NRXN1, PAX8, TBX3, MC4R, PYY, LEPR, ULK4, PHIP, CEP19, DYRK1B, FTO, BRCA2, KCNH2, PPARG, POGZ, FBXO11, TUB, TTC8

ENDOCRINOLOGY

Endocrine disorders can cause a wide range of symptoms, depending on each specific condition. Metabolism and nutrient regulation, reproduction, growth and development can all be regulated by the endocrine system and hormone regulation.

The endocrinology panel can be used to identify genetic variants associated with endocrine disorders which affect the thyroid, parathyroid, pancreas and pituitary gland.

The DNAMyself test analyses genetic variants that are known to affect hormone production and signaling, as well as genes involved in metabolic function via Whole Exome Sequencing (WES).

The test can detect single nucleotide variants (SNVs), small insertions and deletions (indels) in 226 genes.

WT1, PHKG2, NEUROG3, PYGL, SLC26A4, SOX9, KCNJ11, HNF1B, CDKN2B, GLIS3, HNF1A, TACR3, PDX1, FGF8, MKS1, MKRN3, GCM2, DHCR7, NR3C1, PAX4, LDLRAP1, AGL, LMNA, PROP1, ABCG5, NTRK2, RET, TSHB, CUL4B, PTH, BLK, SARS2, DUOX2, SLC16A2, THRA, PCK1, UCP2, PC, AP2S1, CNNM4, GALT, TPO, APOC3, HSD17B3, LDHA, TSHR, NKX2-5, HMGCS2, ALDOA, LPL, GATA4, HADH, IRF6, FBP1, CHD7, TRPM6, BMP15, ERCC3, NIPA2, PAX8, SRD5A2, NOBOX, SRY, APOA1, DUOXA2, AIRE, APOC2, HSD3B2, HMGCL, ABCA1, FOXE1, CYP21A2, GLUD1, ALMS1, CYP11A1, NHLRC1, FGFR1, LEPR, POLG, INSR, PTF1A, RFX6, PHF6, PHKB, THRB, TTC8, PCSK1, POU1F1, NR0B2, CYP11B1, PHKA2, ARMC5, PROKR2, DYRK1B, NR0B1, CDC73, POMC, RSPO1, SECISBP2, POR, CDKN2C, HNF4A, LIPA, CEP290, MAMLD1, PGM1, PPARG, GAA, PFKM, WDPCP, MKKS, IGSF1, DYNC2H1, NNT, PYGM, APOA5, ABCG8, ALDOB, CDKN1A, LMF1, CLDN19, CLCNKB, BSND, ATRX, SLC16A1, CASR, GNRHR, BBS4, CREBBP, BCOR, SIM1, ACAT1, CEP41, EIF2AK3, LAMP2, GNAS, FIG4, MC3R, UCP3, DHH, CREB3L3, OXCT1, PHKA1, MC2R, NR5A1, RBCK1, ZFPM2, GNA11, SDCCAG8, SLC5A5, HESX1, APOB, LHCGR, BBS1, ENO3, GCK, MAP3K1, PCBD1, PRKAG2, MAGT1, ACSF3, BBS12, ADCY3, BBS5, MRAP, PGK1, GYS2, CYP17A1, ARX, KLF11, FOXP3, INS, CDKN1B, GBE1, CLDN16, FXYD2, STAR, FSHR, CNNM2, KSR2, TG, CDKN1C, MC4R, IL17RD, PRKAR1A, LDLR, GATA6, KISS1R, ABCC8, EGF, PCSK9, BBS7, EPM2A, ZFP57, APOE, BBS9, BBS2, FOXL2, NEUROD1, PROK2, SLC2A2, LEP, MEN1, ANOS1, FRAS1, ARL6, BBS10, AMH, KCNJ10, PGAM2, SLC12A3, SLC37A4, NKX2-1, AR, FAM111A, CYP19A1, AMHR2, MAGEL2, WFS1, MPV17, GPIHBP1, PRKAG3, GYS1, GYG1, KCNA1, VPS13B

INFLAMMATORY BOWEL DISEASE (IBD)

Inflammatory bowel disease can cause chronic inflammation in the gastrointestinal track. As a term, it includes two different conditions – Crohn’s disease and Ulcerative colitis.

IBD is an autoimmune disease meaning that lifestyle and genetics play a role on its development.
However up to 20% of IBD cases have a first-degree relative with the condition which gives a strong genetic association to the disease.

Some of the symptoms of IBD can be abdominal pain, diarrhea, rectal bleeding, weight loss, malnutrion and anemia.

The DNAMyself test is recommended for individuals with personal or family history of IBD and exams 125 genes.

The test can detect single nucleotide variants (SNVs), small insertions and deletions (indels).

IL23R, CYBB, AIRE, XIAP, RAB27A, SH2D1A, IL2RB, TRAF3, MVK, LYST, SI, G6PC3, NFAT5, IL2RA, SLC9A3, IKZF1, PIK3R1, TTC37, NCF4, HPS6, DKC1, CASP8, RAC1, RAG1, LRBA, ITCH, TAP2, STAT5B, STXBP3, CD3G, ADAM17, RET, ZNF341, TNFRSF13B, ARPC1B, IL21, IL7R, NOP10, HPS4, CR2, JAK1, ICOS, WAS, WIPF1, RFXANK, RIPK1, STXBP2, FERMT1, SKIV2L, NLRP12, CYBC1, RAG2, STX3, PRF1, ADA, TGFBR1, ANKZF1, DOCK8, CD40LG, RFX5, BACH2, TINF2, POLA1, NOD2, IL2RG, TGFB1, BTK, FUT2, COL7A1, NCF2, STAT3, FCHO1, CIITA, HPS1, LCK, TERT, TNFAIP3, IL21R, CARD8, IL10RA, CD40, IKBKB, ZBTB24, NFKB2, RFXAP, PLCG2, TRIM22, NLRC4, TAP1, MYO5A, NPC1, CD55, RTEL1, DCLRE1C, CD19, TERC, SLCO2A1, LIG4, TTC7A, CARMIL2, ITGB2, CTLA4, C17ORF62, NFKB1, UNC13D, STAT1, AICDA, DUOX2, PTEN, UNG, FOXP3, ZAP70, CD81, SLC37A4, IL10RB, MALT1, CYBA, CHD7, GUCY2C, TGFBR2, IL10, STIM1, RAC2, PIK3CD, MEFV

AUTOIMMUNITY

Autoimmunity can be triggered by genetics and the environment. It is defined as the disease that occurs when the immune responses of an orgasnism acts against its own healthy cells and tissues. Typical examples include celiac disease, Henloch Scholein Pupura (HSP) sarcoidosis, systemic lupus erythematosus (SLE).

In the majority of cases the presence of certain genetic variants increases the risk of developing autoimmune conditions.
The DNAMyself test is recommended for individuals with personal or family history of autoimmune disease and detects genetic variants in 114 genes.

The test can detect single nucleotide variants (SNVs), small insertions and deletions (indels).

ABCC8, C1QB, IL6, C1S, AGRN, WIPF1, NRAS, C1QC, KRAS, CAV1, TTC7A, STAT3, ADA2, POLG, TNFAIP3, LMNB2, PRKCD, NFKB1, C1GALT1C1, ITK, KDM6A, IRF5, LIG4, PNP, C2, C4A, LRBA, ZFP57, VAMP1, TBX1, AIRE, MMP2, GNAS, PLCG2, NLRP1, RAG2, RMRP, PEPD, BTK, TREX1, CD247, DDX41, PTPN22, ITGAM, FCGR2B, IL7R, BANK1, FOXP3, ITCH, MS4A1, SERPING1, CD81, TNFRSF13B, CTLA4, DNASE1L3, ACP5, IL2RG, CD3G, GCK, SLC25A1, DNASE1, CR2, GP1BB, C8A, CD19, TSHR, CASP10, MIF, SEC23B, STAT1, PDX1, TNFRSF13C, SYT2, PAX4, CHD7, PLAGL1, PTEN, STX16, ADA, ICOS, NHEJ1, RAG1, FADD, C1R, ALG14, KMT2D, NFKB2, GALC, FASLG, COMT, C1QA, INS, LCK, STIM1, WAS, MASP2, HLA-DRB1, FOXD3, SNAP25, KCNJ11, AKT2, NBN, STAT4, FAS, FCGR2A, COL13A1, IL2RA, SLC5A7, HLA-B, DCLRE1C, CHAT,IL23R , TNFSF4, TYK2

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